Analysis and prediction of nutritional requirements using structural properties of metabolic networks and support vector machines.

نویسندگان

  • Takeyuki Tamura
  • Nils Christian
  • Kazuhiro Takemoto
  • Oliver Ebenhöh
  • Tatsuya Akutsu
چکیده

Properties of graph representation of genome scale metabolic networks have been extensively studied. However, the relationship between these structural properties and functional properties of the networks are still very unclear. In this paper, we focus on nutritional requirements of organisms as a functional property and study the relationship with structural properties of a graph representation of metabolic networks. In order to examine the relationship, we study to what extent the nutritional requirements can be predicted by using support vector machines from structural properties, which include degree exponent, edge density, clustering coefficient, degree centrality, closeness centrality, betweenness centrality and eigenvector centrality. Furthermore, we study which properties are influential to the nutritional requirements.

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عنوان ژورنال:
  • Genome informatics. International Conference on Genome Informatics

دوره 22  شماره 

صفحات  -

تاریخ انتشار 2010